Award1 Highlight2 Lab Life3 Meeting1 Party1 Research6 Review2
Triphenylphosphonium-modified catiomers enhance in vivo mRNA delivery through stabilized polyion complexation
Jumpei Norimatsu, Hayato L. Mizuno, Takayoshi Watanabe, Takumi Obara, Makoto Makaido, Kouhei Tsumoto, Horacio Cabral, Daisuke Kuroda, and Yasutaka Anraku. Mater. Horiz., 2024, Advance Article Abstract Nanocarriers based on cationic materials play a central role in the success of mRNA-based therapies. Traditionally, amine-bearing lipids and polymers have been successfully employed for creating mRNA-loaded nanocarriers, though…
Tryptophan intercalation in siRNA drives the formation of polymeric micelles with enhanced delivery efficiency
Yuki Nakashima, Wenqian Yang, Pengwen Chen, Keita Masuda, Teahun Hong, and Horacio CabralRSC Pharm., 2024, Advance Article Tryptophan intercalation in siRNA drives the formation of polymeric micelles with enhanced delivery efficiency. Abstract The construction of effective carrier systems is essential for delivering therapeutic small interfering RNA (siRNA). In this study, we present an innovative approach…
Welcome party on April 19th
Welcome Sosuke Takasugi (Left 3), Soichiro Kondo (Left 4), Yuki Kato (Left 5), Renelyn Wolters (Left 6), and Yaqiao Li (Right 3) to our lab!
Graduation ceremony on Mar 21st
In this semester, Li Shang-Wei and Lucas Mixich have graduated from their PhD programs. Congratulations to Dr. Li and Dr. Lucas!
Selective Intracellular Delivery of Antibodies in Cancer Cells with Nanocarriers Sensing Endo/Lysosomal Enzymatic Activity
Pengwen Chen, Wenqian Yang, Yuki Mochida, Shangwei Li, Taehun Hong, Hiroaki Kinoh, Kazunori Kataoka, Horacio Cabral Angew. Chem. Int. Ed. 2024, e202317817. (DOI:10.1002/anie.202317817) Selective Intracellular Delivery of Antibodies in Cancer Cells with Nanocarriers Sensing Endo/Lysosomal Enzymatic Activity Abstract: The differential enzymatic activity in the endo/lysosomes of particular cells could trigger targeted endosomal escape functions, enabling…
Nanoassemblies of heptamethine cyanine dye-initiated poly(amino acid) enhance ROS generation for effective antitumour phototherapy
Pengwen Chen, Shangwei Li, Zhining Xu, Horacio Cabral Nanoscale Horiz., 2024, Advance Article (DOI:10.1039/D3NH00584D)Nanoassemblies of heptamethine cyanine dye-initiated poly(amino acid) enhance ROS generation for effective antitumour phototherapy Abstract: Phototherapy shows great potential for pinpoint tumour treatment. Heptamethine cyanine dyes like IR783 have high potential as agents for antitumour phototherapy due to their inherent tumour targeting…
Nanocarriers address intracellular barriers for efficient drug delivery, overcoming drug resistance, subcellular targeting and controlled release
Jing Liu, Horacio Cabral, Peng Mi Adv. Drug Deliv. Rev., 115239 (2024) (DOI:10.1016/j.addr.2024.115239) Nanocarriers address intracellular barriers for efficient drug delivery, overcoming drug resistance, subcellular targeting and controlled release Abstract: The cellular barriers are major bottlenecks for bioactive compounds entering into cells to accomplish their biological functions, which limits their biomedical applications. Nanocarriers have demonstrated high potential and benefits for encapsulating bioactive…
Workshop with Seoul National University on ‘Data-Driven Biomedical Innovation’
The University of Tokyo and Seoul National University stand as global leaders in research and education, catering to the growing needs in advanced bioengineering studies. The commitment to these perspectives and responsibilities propels researchers within these institutions to achieve pioneering discoveries and develop innovative products and services with heightened performance. In light of these achievements,…
