Award1 Highlight2 Lab Life3 Meeting1 Party1 Research6 Review2
Graduation Ceremony on 20th Sept
Congratulations to Chen, Norimatsu, and Ajimi!
Farewell Party on 17th Sept
Congratulations to Chen, Norimatsu, and Osama!
Triphenylphosphonium-modified catiomers enhance in vivo mRNA delivery through stabilized polyion complexation
Jumpei Norimatsu, Hayato L. Mizuno, Takayoshi Watanabe, Takumi Obara, Makoto Makaido, Kouhei Tsumoto, Horacio Cabral, Daisuke Kuroda, and Yasutaka Anraku. Mater. Horiz., 2024, Advance Article Abstract Nanocarriers based on cationic materials play a central role in the success of mRNA-based therapies. Traditionally, amine-bearing lipids and polymers have been successfully employed for creating mRNA-loaded nanocarriers, though…
Tryptophan intercalation in siRNA drives the formation of polymeric micelles with enhanced delivery efficiency
Yuki Nakashima, Wenqian Yang, Pengwen Chen, Keita Masuda, Teahun Hong, and Horacio CabralRSC Pharm., 2024, Advance Article Tryptophan intercalation in siRNA drives the formation of polymeric micelles with enhanced delivery efficiency. Abstract The construction of effective carrier systems is essential for delivering therapeutic small interfering RNA (siRNA). In this study, we present an innovative approach…
Welcome party on April 19th
Welcome Sosuke Takasugi (Left 3), Soichiro Kondo (Left 4), Yuki Kato (Left 5), Renelyn Wolters (Left 6), and Yaqiao Li (Right 3) to our lab!
Graduation ceremony on Mar 21st
In this semester, Li Shang-Wei and Lucas Mixich have graduated from their PhD programs. Congratulations to Dr. Li and Dr. Lucas!
Selective Intracellular Delivery of Antibodies in Cancer Cells with Nanocarriers Sensing Endo/Lysosomal Enzymatic Activity
Pengwen Chen, Wenqian Yang, Yuki Mochida, Shangwei Li, Taehun Hong, Hiroaki Kinoh, Kazunori Kataoka, Horacio Cabral Angew. Chem. Int. Ed. 2024, e202317817. (DOI:10.1002/anie.202317817) Selective Intracellular Delivery of Antibodies in Cancer Cells with Nanocarriers Sensing Endo/Lysosomal Enzymatic Activity Abstract: The differential enzymatic activity in the endo/lysosomes of particular cells could trigger targeted endosomal escape functions, enabling…
