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Triphenylphosphonium-modified catiomers enhance in vivo mRNA delivery through stabilized polyion complexation
Jumpei Norimatsu, Hayato L. Mizuno, Takayoshi Watanabe, Takumi Obara, Makoto Makaido, Kouhei Tsumoto, Horacio Cabral, Daisuke Kuroda, and Yasutaka Anraku. Mater. Horiz., 2024, Advance Article Abstract Nanocarriers based on cationic materials play a central role in the success of mRNA-based therapies. Traditionally, amine-bearing lipids and polymers have been successfully employed for creating mRNA-loaded nanocarriers, though…