Latest News
Top-viewed paper in Advacned Science!
Our lab’s paper, ‘An IL-12-based nano cytokine safely potentiates anticancer immunity through spatiotemporal control of inflammation to eradicate advanced cold tumors,’ was awarded the top-viewed paper in Advanced Science!
Bone marrow vessels are hyperpermeable to macromolecules and nanoscale medicine in a size-dependent manner
John D. Martin, Kazuko Toh, Margaret R. Martin, Pengwen Chen, Chenyu Wang, Kazunori Igarashi, Fotios Mpekris, Triantafyllos Stylianopoulos, Matthew D. Stuber, Kazunori Kataoka, Horacio Cabral JCR. 2025 Abstract Bone marrow (BM) has roles in health and disease, so systemically administered nanocarriers (NCs) targeting or avoiding BM are desirable. While the hydrodynamic diameter of NCs can be tuned to target or avoid various organs, the size dependence of extravasation from BM vessels is unknown. To clarify the…
Top Cited Article!
Our work, ‘Polymer-Based mRNA Delivery Strategies for Advanced Therapies,’ published in Advanced Healthcare Materials, was among the top 10 most cited papers in the journal in 2023!
Secondary Structure-Guided Assembly of Uniform Disk-Like Polymeric Micelles Incorporating Hydrophobic Platinum Drugs for Improved Tumor Targeting
Yuki Mochida, Horacio Cabral, Yutaka Miura, Kensuke Osada, Nobuhiro Nishiyama, Kazunori Kataoka Chem. Mater. 2025 Abstract Tailoring the secondary structure of a poly(amino acid) offers a powerful approach for precisely assembling nanostructures for biomedical applications. In this study, we demonstrated that the poly(α-l-glutamic acid) segment of the poly(ethylene glycol)-poly(α-l-glutamic acid) block copolymer forms an α-helix…
