John D. Martin, Kazuko Toh, Margaret R. Martin, Pengwen Chen, Chenyu Wang, Kazunori Igarashi, Fotios Mpekris, Triantafyllos Stylianopoulos, Matthew D. Stuber, Kazunori Kataoka, Horacio Cabral  JCR. 2025 Abstract Bone marrow (BM) has roles in health and disease, so systemically administered nanocarriers (NCs) targeting or avoiding BM are desirable. While the hydrodynamic diameter of NCs can be tuned to target or avoid various organs, the size dependence of extravasation from BM vessels is unknown. To clarify the…

Yuki Mochida, Horacio Cabral, Yutaka Miura, Kensuke Osada, Nobuhiro Nishiyama, Kazunori Kataoka Chem. Mater. 2025 Abstract Tailoring the secondary structure of a poly(amino acid) offers a powerful approach for precisely assembling nanostructures for biomedical applications. In this study, we demonstrated that the poly(α-l-glutamic acid) segment of the poly(ethylene glycol)-poly(α-l-glutamic acid) block copolymer forms an α-helix…

Qingzhen Zhu, Horacio Cabral, Kaori Sugihara ACS Appl. Polym. Mater. 2025 Abstract Membrane-active peptides, including antimicrobial peptides, cell-penetrating peptides, and ionophores, often require time-consuming and costly techniques for functional characterization, creating a bottleneck in drug screening. In this study, we present a high-throughput, high-sensitivity peptide functional assay utilizing the mechanochromic polymer polydiacetylene (PDA). We demonstrate…

Yasuhiro Nakagawa, Hayato Laurence Mizuno, Yuta Ushimaru, Jumpei Norimatsu, Kazunori Igarashi, Keita Masuda, Madoka Takai, Yasutaka Anraku, and Horacio Cabral Mol. Syst. Des. Eng., 2024, Advance Article Abstract Visualizing singlet oxygen (1O2) in biological systems could greatly enhance our understanding of its biological roles and offer new diagnostics and therapeutics. However, 1O2 is unstable and…