Dual-labelled polymeric micelles for singlet oxygen reporting in biological systems

Publication

Yasuhiro Nakagawa, Hayato Laurence Mizuno, Yuta Ushimaru, Jumpei Norimatsu, Kazunori Igarashi, Keita Masuda, Madoka Takai, Yasutaka Anraku, and Horacio Cabral

Mol. Syst. Des. Eng., 2024, Advance Article

Abstract

Visualizing singlet oxygen (1O2) in biological systems could greatly enhance our understanding of its biological roles and offer new diagnostics and therapeutics. However, 1O2 is unstable and highly reactive, making its detection in living systems a significant challenge. To address this, we have developed dually-labelled polymeric micelles designed to trace both the location and levels of 1O2.