Nanomedicine has high potential for early detection of disorders and achieving unprecedented treatment efficacies, even against intractable diseases, by effectively overcoming biological barriers and controlling the function of bioactive agents in the body. In our group, we aim to develop nanomedicines for effective diagnosis and therapy through the precise sensing of targets in the body and the triggering of the nanomedicines’ activity at specific sites, modulating the behavior of the loaded drugs, even at the subcellular level.
The aspects involved in the design of successful nanomedicines and the interplay of nanomedicines with the biological interface are major interests of the lab, focusing on the ultimate translation of nanomedicine strategies to humans.
1. Polymeric nanocarriers for mRNA delivery
mRNA-based therapies have revealled great potentials in clinic, including the vaccines against COVID-19. Designing efficient delivery systems is crucial for developing effective mRNA therapeutics. In our lab, we are applying polymeric nanocarriers for stable and precise delivery of mRNA into different tissues, to generate various mRNA-based therapies including anti-virus vaccines, anti-cancer vaccines, in situ immune cell engineering, and cancer immunotherapies.
2. Polymeric nanomedicines for cancer immunotherapy
Immunotherapies have been approved for clinical cancer treatment, however they sitll meet the problem of efficacy and safety. We are trying to utilize polymeric delivery system to mediate precise tumor-targeted delivery of immunotherapeutics, including cytokines, antibodies, nucleic acids.
